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  • Title: The influence of the input function on quantitative rCBF by the Xe/CT method.
    Author: von Oettingen G, Bergholt B, Ostergaard L, Rasmussen M, Gyldensted C, Astrup J.
    Journal: Keio J Med; 2000 Feb; 49 Suppl 1():A11-5. PubMed ID: 10750328.
    Abstract:
    Measurements of rCBF by the Xe/CT method are based on the assumption of identity between the end-tidal xenon curve which is applied as input function, and the arterial xenon curve being the true input function to the brain. In this study corresponding end-tidal and arterial xenon curves were measured in an experimental animal model (part 1) and in 5 patients with traumatic brain injury (part 2) and used for rCBF calculation. In both studies rCBF was underestimated by using the end-tidal xenon concentration curve as brain input function. In part 1 rCBF underestimation was depended on pulmonary gas exchange; high or low levels of rCBF; tissue type; and xenon inhalation protocols. In part 2 the mean rCBF underestimation was 18.8 +/- 8.3%. In conclusion, non-invasive estimate of the input function should be considered as a source of error when defining quantitative blood flow values e.g. the flow thresholds of ischaemic infarction.
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