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  • Title: Recognition and management of Kawasaki disease.
    Author: Han RK, Sinclair B, Newman A, Silverman ED, Taylor GW, Walsh P, McCrindle BW.
    Journal: CMAJ; 2000 Mar 21; 162(6):807-12. PubMed ID: 10750471.
    Abstract:
    Kawasaki disease is the leading cause of acquired heart disease in children in the developed world, with coronary artery aneurysms occurring in up to 25% of untreated cases. The mean annual incidence of Kawasaki disease across Canada is about 13 per 100,000 children less than 5 years of age, based on hospital discharge data from 1990 to 1995. The cause remains unknown, and the diagnosis is based on the same clinical criteria used to describe the disease over 30 years ago. However, nonspecific clinical features, evolving presentations and atypical or incomplete presentations make early diagnosis and timely treatment difficult. Delays in diagnosis and treatment, which occur more frequently in older children, are associated with an increased risk of coronary artery aneurysms. Hence, high diagnostic suspicion and prompt referral are required to reduce the rate of cardiac complications.
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