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  • Title: [Low expression of nm23-H1 mRNA and its protein in breast cancer].
    Author: Guo W, Wang Y, Zhuang X, Bai Y, Zhang J.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2000 Apr; 17(2):91-3. PubMed ID: 10751528.
    Abstract:
    OBJECTIVE: To explore the expression of nm23-H1 mRNA and its protein in breast cancer and its correlation to the biologic behavior. METHODS: RT-PCR and immunohistochemical method were employed to detect the expression of nm23-H1 mRNA and its protein in 58 breast cancer tissues. RESULTS: Low level expression of nm23-H1 mRNA and protein was shown in 44.8% and 48.2% of examined cases respectively. The low expression of nm23-H1 mRNA was correlated, but not always parallel to the protein expression. The low level expression of nm23-H1 mRNA or the protein was significantly associated with lymphatic metastasis of the cancer. CONCLUSION: Examination of nm23-H1 expression may be of significance in evaluating metastatic potentiality and prognosis of breast cancer.
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