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  • Title: Diabetic retinopathy is associated with decreased serum levels of free IGF-I and changes of IGF-binding proteins.
    Author: Feldmann B, Jehle PM, Mohan S, Lang GE, Lang GK, Brueckel J, Boehm BO.
    Journal: Growth Horm IGF Res; 2000 Feb; 10(1):53-9. PubMed ID: 10753593.
    Abstract:
    In patients with diabetic retinopathy, elevated serum levels of total circulating insulin-like growth factor-I (IGF-I) have been implicated as an important mediator of the disease. There is no study, however, measuring free IGF-I levels in patients with diabetic retinopathy which mediate the biological effects of IGF-I and are modulated by a complex system of six specific IGF binding proteins (IGFBPs) and several IGFBP proteases.
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