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  • Title: [An immunohistochemical study of the steroid hormone receptors in endometrial hyperplasia].
    Author: Teleman S, Hilgarth M, Freudenberg N, Bettendorf H, Mihailovici MS.
    Journal: Rev Med Chir Soc Med Nat Iasi; 1999; 103(1-2):138-41. PubMed ID: 10756900.
    Abstract:
    AIM: Evaluation of the estrogen and progesterone receptors (ER and PR) in different degrees of endometrial hyperplasias. METHODS: 10 cases of each degree of endometrial hyperplasia (simple, complex and atypical) were analyzed using the avidin-biotin-peroxidase technique and monoclonal antibodies applied to formalin-fixed, paraffin-embedded tissue. RESULTS: We found similar, high level of both ER and PR in simple and complex hyperplasias and a significant decrease of these in atypical hyperplasia. CONCLUSIONS: Endometrial hyperplasias develop in a setting of estrogen excess. This explains the high level of endometrial receptors and the response to progesterone in typical hyperplasia. In atypical hyperplasia, the decrease of steroid receptors results in a low sensibility of this lesion to progestative therapy, but there are cases with high receptor levels which could have a chance for hormonal therapy.
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