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  • Title: Proinflammatory and regulatory cytokine levels in AIDS cachexia.
    Author: Baronzio G, Zambelli A, Comi D, Barlocco A, Baronzio A, Marchesi P, Gramaglia A, Castiglioni E, Mafezzoni A, Beviglia E, Crespi F, Cargnel AI, Pravettoni G.
    Journal: In Vivo; 1999; 13(6):499-502. PubMed ID: 10757044.
    Abstract:
    The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflammatory cytokines (Interleukin-1, Interleukin-6, Tumor necrosis Factor alpha) and a decrease in regulatory cytokines such as Interleukin-12 were found. A significant correlation resulted between weight loss and Interleukin-1 beta and 6. A negative correlation between Interleukin-1 and 12 was noted, indicating that this last cytokine has an important regulatory role also in advanced state of the disease.
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