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  • Title: [The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals].
    Author: Morozov IS, Efimova LP, Kryzhanovskiĭ SA.
    Journal: Eksp Klin Farmakol; 2000; 63(1):33-6. PubMed ID: 10763107.
    Abstract:
    Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase. Bromantan also weakly increases the pressor effects of adrenaline and noradrenaline. In anaesthetized cats, bromantan modifies the shape of the amplitude-frequency characteristic of EEG measured in the upper cervical ganglion, reducing (against the initial level) the induced potential in the frequency range of the preganglionic fiber stimulation (1-10 and 25-30 Hz). In freely moving rats, capable of well-learnt Sidman's [correction of Seedman's] operant activity, bromantan showed a reliable tendency to decrease the rate of noradrenaline and adrenaline excretion with urine.
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