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  • Title: [Isolation and study of recombinant strains of Salmonella typhimurium SL 7207, producing HBcAG and HBcAG-HBs].
    Author: Karpenko LI, Ignat'ev GM, Kozhina EM, Kashentseva EA, Poryvaeva VA, Melamed NV, Baĭborodin SI, Smirnova OIu, Il'ichev AA.
    Journal: Vopr Virusol; 2000; 45(2):10-4. PubMed ID: 10765543.
    Abstract:
    Recombinant strains producing hepatitis B virus (HBcAg) core protein and chimeric core protein exposing on its surface the major immunogenic epitope of HBsAg (HBcAg-HBs) were constructed on the base of attenuated S. typhimurium SL 7202 strain. The resultant Salmonella strains produced proteins which were capable of self-assembly into virus-like particles and showed antigenic properties of both core and surface hepatitis B proteins. A single rectal immunization with recombinant S. typhimurium induced humoral and cellular immune response to HBcAg and HBsAg. Specific anti-HBcAg were detected in animal sera and intestinal tissues, which indicated the formation of specific mucosal immunity.
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