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  • Title: Detection of tenascin-C in surgically excised choroidal neovascular membranes.
    Author: Nicolò M, Piccolino FC, Zardi L, Giovannini A, Mariotti C.
    Journal: Graefes Arch Clin Exp Ophthalmol; 2000 Feb; 238(2):107-11. PubMed ID: 10766277.
    Abstract:
    BACKGROUND: Increase of tenascin-C (TN-C) expression has been found in pathologic tissues in which angiogenesis occurs. The aim of this study was to investigate TN-C expression in human choroidal neovascularization (CNV). METHODS: Ten choroidal neovascular membranes were surgically removed from 10 patients with age-related macular degeneration (n=6) and multifocal choroiditis (n=4). All membranes underwent immunohistochemical evaluation using monoclonal antibodies against TN-C and factor VIII. RESULTS: All membranes were positive for TN-C, which was abundantly and diffusely expressed in the extracellular matrix. CONCLUSIONS: Our results support the concept that TN-C has a role in cell proliferation and neovascularization in humans. TN-C, as a marker of angiogenesis, may provide novel rationales for the development of pharmacologic therapies for neovascular disorders, particularly CNV.
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