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  • Title: Detection and identification of labeled DNA by surface enhanced resonance Raman scattering.
    Author: Graham D, Mallinder BJ, Smith WE.
    Journal: Biopolymers; 2000; 57(2):85-91. PubMed ID: 10766959.
    Abstract:
    The detection of specific sequences of DNA bases in a single strand can be achieved by hybridization of a known sequence of synthetic DNA. Due to the low concentrations usually used, a fluorescent label is required to detect the probe. Surface enhanced resonance Raman scattering (SERRS) also has the required sensitivity and provides a specific set of signals that are more applicable to discrimination of a number of probes without separation. A reliable SERRS method is reported here using two probes specifically designed for SERRS. It was possible to detect a 2 x 10(-12)M solution of labeled DNA, which illustrated the sensitive nature of SERRS for DNA analysis.
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