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  • Title: Theophylline-induced changes in the activity of carnitine palmitoyltransferase in rat cardiac tissues.
    Author: Alhomida AS.
    Journal: Toxicology; 2000 Apr 14; 145(2-3):185-93. PubMed ID: 10771142.
    Abstract:
    This study is conducted to investigate the influence of oral theophylline administration (100 mg/kg bw per day) on the activity of carnitine palmitoyltransferase (CPT) in cardiac tissues of rats for 5-week interval treatments. Results showed significant increase in the activity of CPT was observed in cardiac tissues of theophylline-treated groups as compared to either control or placebo groups. Moreover, the results showed positive correlations between the cardiac concentrations of long-chain acylcarnitine (LC) and the activity of CPT and between plasma concentrations of LC and the cardiac concentrations of LC (P<0.01), respectively. The observed changes in activity of cardiac CPT might be due to the result from theophylline- enhanced decrease the sensitivity of CPT to inhibition by malonyl-CoA and/or from theophylline-enhanced mobilization of lipid from adipose tissues which consequently stimulated an increased carnitine transport into the tissues to form palmitoylcarnitine groups for subsequent beta-oxidation inside the mitochondria. Thus, these accumulations of acylcarnitine groups in mitochondria may increase the catalytic action of CPT.
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