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  • Title: Crystallization and preliminary crystallographic analysis of a new crystal form of arylsulfatase A isolated from human placenta.
    Author: Lewinski K, Chruszcz M, Ksiazek D, Laidler P.
    Journal: Acta Crystallogr D Biol Crystallogr; 2000 May; 56(Pt 5):650-2. PubMed ID: 10771439.
    Abstract:
    Depending on pH, arylsulfatase A exists in solution as a dimer or as an octamer. The enzyme isolated from human placenta was crystallized at pH 5.4 in a new crystal form with space group C2, unit-cell parameters a = 154.0, b = 190.3, c = 112.5 A, beta = 122.4 degrees and four subunits in the asymmetric unit. At pH 6.5-6.7, tetragonal crystals are obtained that are isomorphous to the known crystals of recombinant arylsulfatase A obtained at pH 5.0-5.4. The crystal structure of both forms was determined by the molecular-replacement method. The monoclinic crystals contain octamers of the same type as found in the tetragonal form.
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