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  • Title: Prenatal diagnosis of thalassemia in Songklanagarind Hospital in southern Thailand.
    Author: Kor-anantakul O, Suwanrath CT, Leetanaporn R, Suntharasaj T, Liabsuetrakul T, Rattanaprueksachart R.
    Journal: Southeast Asian J Trop Med Public Health; 1998 Dec; 29(4):795-800. PubMed ID: 10772567.
    Abstract:
    A thalassemia screening program for pregnant women has been established in Songklanagarind Hospital since 1992. After genetic counseling, a total of 5078 pregnant women accepted entry into a screening program for thalassemia. Couples at risk who should receive prenatal diagnosis were 2.8%. Total cases who accepted prenatal diagnosis were 135. Total clinical cases were 40 (29.6%) with achievement by prenatal diagnosis of 33 cases (82.5%). Genetic amniocentesis is the most acceptable method for prenatal diagnosis. Five cases (12.5%) were misdiagnosed due to contamination of maternal blood cells in amniotic fluid cases. Questionable results were reported in 2 cases (5%). Abortion occurred in one case (0.7%). Improvement of surgical technic in prenatal diagnosis reduced the complications and contamination of maternal cells. This program shows the feasibility of prevention and control of thalassemia disease in southern Thailand.
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