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  • Title: Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep.
    Author: Baron TG, Madec JY, Calavas D, Richard Y, Barillet F.
    Journal: Neurosci Lett; 2000 Apr 28; 284(3):175-8. PubMed ID: 10773427.
    Abstract:
    We compared the glycoform pattern of the abnormal prion protein (PrP(Sc)) detected by immunoblotting in 21 sheep with natural scrapie, from 21 different outbreaks identified in France since 1996, with a bovine spongiform encephalopathy (BSE)-infected sheep. All the natural scrapie isolates had a higher molecular mass of the unglycosylated PrP(Sc) than in BSE-infected sheep. In the latter case, this molecular mass appeared identical to that found in the CH 1641 experimental scrapie strain (type C pattern), whereas in natural scrapie cases it was similar to that found in the SSBP/1 experimental scrapie strains. These results suggest that all French natural scrapie isolates studied so far would belong, as SSBP/1, to the group of scrapie cases with type A electrophoretic pattern.
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