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  • Title: Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease.
    Author: Hahn A, Claviez A, Brinkmann G, Altermatt HJ, Schneppenheim R, Stephani U.
    Journal: Neuropediatrics; 2000 Feb; 31(1):42-4. PubMed ID: 10774996.
    Abstract:
    Paraneoplastic cerebellar degeneration (PCD) is a rare neurological complication in adults with extracerebral neoplasms. It is characterized by a diffuse cerebellar dysfunction, usually leading to severe neurological sequelae. In childhood, this complication is extremely rare. We report on PCD as primary manifestation of Hodgkin disease (HD) in a thirteen-year old boy. On magnetic resonance imaging, irreversible atrophy of the cerebellum developed within three months. Antibodies against Purkinje cells were detectable at diagnosis and normalised after successful treatment of the lymphoma. Cerebellar symptoms, however, only partially resolved. The necessity of a search for a malignant tumour is emphasised in the presence of an otherwise unexplained, subacutely developing, diffuse cerebellar dysfunction.
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