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  • Title: [Effectiveness of treatment with metformin in patients with type 2 diabetes mellitus poorly controlled with insulin treatment].
    Author: Boronat Cortés M, Marrero Arencibia D, La Roche Brier F, Ojeda Pino A, Carrillo Domínguez A, Nóvoa Mogollón FJ.
    Journal: Rev Clin Esp; 2000 Feb; 200(2):74-6. PubMed ID: 10776038.
    Abstract:
    Combined treatment with insulin plus metformin could be a good alternative to improve the glycemic control in patients with type 2 diabetes mellitus poorly controlled with insulin therapy. We retrospectively studied 21 obese insulin-treated type 2 diabetic patients with deficient metabolic control (HbA1c 9.2 +/- 1.2%) who were treated with metformin for a minimum of 8 months. After 4 months of treatment, a significant decrease in the percentage of HbA1c was observed (delta HbA1c -1.07 +/- 1.12%; p < 0.01), with maintained values since then. Non changes in body weight or insulin requirement were noted. Our results suggest that the addition of metformin to insulin treatment is a safe and effective strategy for the improvement of glycemic control among obese type 2 diabetic patients.
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