These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mechanism of ribosome RNA apurinic site specific lyase.
    Author: Sawasaki T, Morishita R, Ozawa A, Ogasawara T, Madin K, Endo Y.
    Journal: Nucleic Acids Symp Ser; 1999; (42):257-8. PubMed ID: 10780477.
    Abstract:
    A new enzyme, which we named ribosome RNA apurinic site specific lyase (RALyase), has been characterized. The enzyme specifically cleaves a phosphodiester bond at the apurinic site in the sarcin/ricin domain of 28S rRNA in ribosomes. The cut ends of wheat 28S rRNA were determined as 5'---GUACG-alpha-hydroxy-alpha, beta-unsaturated aldehyde and pGAGGA---3' for the 3' fragment, demonstrating that the enzyme catalyzes the beta-elimination reaction.
    [Abstract] [Full Text] [Related] [New Search]