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  • Title: Prenatal diagnosis and elective termination of neural tube defects in Hawaii, 1986-1997.
    Author: Forrester MB, Merz RD.
    Journal: Fetal Diagn Ther; 2000; 15(3):146-51. PubMed ID: 10781998.
    Abstract:
    OBJECTIVE: To determine the influence of various factors on the prenatal diagnosis and elective termination of neural tube defects (NTDs) in Hawaii in 1986-1997. METHODS: Data from a birth defects registry were analyzed and included 245 cases. RESULTS: 74% of the cases were prenatally diagnosed and 48% were terminated. Anencephaly was more likely to be prenatally diagnosed and electively terminated than spina bifida or encephalocele. Other factors such as maternal age, race/ethnicity, place of residence, and elevated maternal serum alpha-fetoprotein influenced the prenatal diagnosis and/or elective termination of NTD-affected pregnancies. However, a given factor may influence prenatal diagnosis and elective termination in different ways. CONCLUSIONS: Various diagnostic and demographic factors can influence the prenatal diagnosis and the subsequent termination of NTD-affected pregnancies.
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