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  • Title: Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.
    Author: Xia Y, Yang ZY, Xia P, Bastow KF, Nakanishi Y, Lee KH.
    Journal: Bioorg Med Chem Lett; 2000 Apr 17; 10(8):699-701. PubMed ID: 10782667.
    Abstract:
    New 4',5',2,3,4-substituted 2'-amino chalcones were synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines. Several compounds displayed significant cytotoxicity. The most promising lead molecule (10) also had high activity toward multi-drug resistant KB-VIN, and ovarian 1A9 cell lines. 2'-Amino chalcones demonstrated significantly increased antitumor activity compared with the corresponding chalcones, while, the epoxide derivatives generally showed greatly reduced activity.
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