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  • Title: [Physiological role of fats in the process of penicillin biosynthesis].
    Author: Lur'e LM, Stepanova NE, Bartoshevich IuE, Levitov MM.
    Journal: Antibiotiki; 1979 Feb; 24(2):86-92. PubMed ID: 107853.
    Abstract:
    The level of penicillin production in the presence of whale oil was shown to be higher. The stimulating effect of the oil was connected with accumulation of large biomass rather than with its specific effect on the biosynthesis. At the beginning of the process the oil eliminated the biomass accumulation lag-phase connected with beta-galactosidase repression by glucose. During the second part of the fermentation process the oil acclerated the culture growth in the presence of lactose. The rate of the oil consumption calculated for carbon was higher than that of the lactose utilization. The presence of the oil in the medium did not prevent the lactose consumption.
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