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  • Title: An experimental vaccine providing heterologous protection for Leishmania species in murine model.
    Author: Bebars MA, el Serougi AO, Makled KM, Mikhael EM, Abou Gamra MM, el Sherbiny M, Mohareb AW, Mohammed EA.
    Journal: J Egypt Soc Parasitol; 2000 Apr; 30(1):137-56. PubMed ID: 10786026.
    Abstract:
    Five groups each of 20 BALB/C mice were immunized by heat killed L. donovani promastigotes. Two groups served as control. Each group of mice was subdivided into 2 equal subgroups and challenged with either L. donovani or L. major. The results revealed a high cross reactivity paralleled by a high cross protection between L. donovani and L. major. Heat killed L. donovani promastigotes super-passed other tested SDS-PAGE fractionated and eluted L. d. fractions identified by immune BALB/c mice in providing protection against both L. donovani and L. major. The percentage of protection (reduction in parasite burden) offered by each vaccine was as follows: 80.21%, 36.11%, 9.29%, 33.44% and 17.48% respectively against challenge infection with L. donovani and 3.012 x 10(4), 1.095 x 10(4), 6.054 x 10(2), 2.409 x 10(4), and 3.34 x 10(2), respectively against challenge infection with L. major.
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