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  • Title: The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy.
    Author: Beattie EJ, Martini N, Rosen G.
    Journal: Cancer; 1975 Mar; 35(3):618-21. PubMed ID: 1078639.
    Abstract:
    This report concerns a consecutive group of 10 children with metastatic osteogenic sarcoma treated with combined surgery and chemotherapy. Eight of 10 patients had thoracotomy prior to chemotherapy, and 2 after an initial trial of chemotherapy. Sequential chemotherapy was given to all patients and consisted of vincristine, high-dose methotrexate with citrovorum factor rescue, cyclophosphamide, and Adriamycin. Chemotherapy was continuously recycled for 1 year. The encouraging results obtained with these 10 patients are demonstrated with emphasis on the value of aggressive multidisciplinary therapy in salvaging patients with advanced metastatic osteogenic sarcoma.
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