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  • Title: Preliminary evidence for cell-mediated immunity in cross-protection among group A arboviruses.
    Author: Peck RD, Brown A, Wust CJ.
    Journal: J Immunol; 1975 Feb; 114(2 Pt 1):581-4. PubMed ID: 1079033.
    Abstract:
    Unfractionated and T cell-enriched populations from spleens of mice immunized with Sinbdis virus confer cross-protection against Semliki forest virus challenge in recipient mice. Both Group A viruses are serologically related, but not by tests for cross-neutralizing antibody. The protection in mice persisted for three consecutive cell passages in uninfected mice. The results suggest that cell-mediated immunity accounts for cross-protection.
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