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  • Title: Interactions of inflammatory mediators and low pH not influenced by capsazepine in rat cutaneous nociceptors.
    Author: Habelt C, Kessler F, Distler C, Kress M, Reeh PW.
    Journal: Neuroreport; 2000 Apr 07; 11(5):973-6. PubMed ID: 10790866.
    Abstract:
    The rat skin-saphenous nerve preparation was used to record from mechano-heat sensitive C-fibers whose receptive fields were superfused with various solutions of low pH and of bradykinin, serotonin and prostaglandin E2. Only synchronous application of protons and mediators resulted in a significant nearly three-fold augmentation of the nociceptive pH response, and capsazepine (10(-5) M) did not block this short-lived enhancement. Thus, it does not seem to involve the capsaicin receptor (VRI) which is in contrast to a previous finding from cultured sensory neurons.
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