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  • Title: Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva.
    Author: Hall R, Boulter NR, Brown CG, Wilkie G, Kirvar E, Nene V, Musoke AJ, Glass EJ, Morzaria SP.
    Journal: Parasite Immunol; 2000 May; 22(5):223-30. PubMed ID: 10792761.
    Abstract:
    Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.
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