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  • Title: The role of the thymus in spontaneous autoimmune thyroiditis.
    Journal: Ann N Y Acad Sci; 1975 Feb 28; 249():116-24. PubMed ID: 1079426.
    Abstract:
    In two models of genetically determined, spontaneous autoimmune thyroiditis, neonatal thymectomy increases the incidience and severity of disease. The simpliest explanation is that the thymus, or thymus-derived cells, normally exert a suppressive effect on the autoimmune response to thyroglobulin in addition to the helper function that is necessary to initiate the autoimmune reaction.
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