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  • Title: [Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
    Author: Gueye L, Sene MC, Sene F, Mesdjian E, Farnarier G, Diagne M, Ndiaye IP.
    Journal: Dakar Med; 1999; 44(1):1-7. PubMed ID: 10797976.
    Abstract:
    The aim of our study was to emphasize factors which support pharmaco-resistance in Senegal. For this purpose, 23 patients with partial or generalized epilepsy were studied, after determining the plasmatic concentration of the antiepileptic drugs. The aetiologies were numerous: encephalitis, injuries, neonatal encephalitis. All patients were under traditional treatment before coming to the hospital. So antiepileptic drugs were taken a long time after the beginning of epilepsy later, they were Phenobarbital, Carbamazepine, Phenytoin, and Valproic acid. Only seven patients had sufficient plasmatic level of the antiepileptic drug. The low socio-economic conditions of patients which limit the choice of the most adapted drug in each case, is one of the most important reason of the pharmaco-resistance. Another factor of the pharmaco-resistance is cultural and is linked with the absence of notion of chronic disease necessitating long and regular treatment in senegalese traditional society.
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