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  • Title: Effect of whole-body irradiation on transcription in the rat thymus.
    Author: Patil MS, Pradhan DS, Sreenivasan A.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1975 Apr; 27(4):363-70. PubMed ID: 1079799.
    Abstract:
    Studies were carried out to elucidate the mechanism underlying the impairment in RNA synthesis in the rat thymus after whole-body exposure to X-rays (1000 rad). The ability of thymus nuclei to catalyse RNA polymerization in vitro was adversely affected in irradiated rats. Further experiments showed that whole-body irradiation caused a considerable decrease in both the activity of RNA polymerase and the template efficiency of chromatin but not in that of DNA isolated from chromatin. These radiation-induced changes in transcription seem to arise partly from the direct effect of radiation on the thymus itself and partly from the abscopal mechanism(s).
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