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  • Title: The 5-HT(1A) antagonist WAY 100635 can block the low-dose locomotor stimulant effects of cocaine.
    Author: Carey R, Damianopoulos E, DePalma G.
    Journal: Brain Res; 2000 Apr 17; 862(1-2):242-6. PubMed ID: 10799692.
    Abstract:
    Cocaine treatments of 2.5, 5.0, 10.0 and 15.0 mg/kg induced dose-dependent increases in locomotor behavior. This cocaine-induced increase in locomotion was blocked if the animals were administered the selective 5-HT(1A) antagonist, WAY 100635 (0.4 mg/kg) prior to the cocaine treatment. The 0.4-mg/kg dose of WAY 100635 did not affect locomotor behavior or alter cocaine availability in brain.
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