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  • Title: N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation.
    Author: Ringdén O, Remberger M, Lehmann S, Hentschke P, Mattsson J, Klaesson S, Aschan J.
    Journal: Bone Marrow Transplant; 2000 May; 25(9):993-6. PubMed ID: 10800069.
    Abstract:
    Three patients developed veno-occlusive disease of the liver (VOD) after allogeneic stem cell transplantation. On the day after diagnosis, N-acetylcysteine (NAC) was given, initially in loading doses and thereafter 50-150 mg/kg/day for 12 to 31 days. The maximum bilirubin levels were 137, 58 and 138 mmol/l in the three patients, respectively. After the introduction of NAC, bilirubin, aspartate aminotransferase, sIL-2 receptor and IL-8 decreased. All three patients achieved normal bilirubin levels and prothrombin times. To conclude, NAC may be useful for treatment of VOD.
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