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  • Title: The Mre11 complex and ATM: collaborating to navigate S phase.
    Author: Petrini JH.
    Journal: Curr Opin Cell Biol; 2000 Jun; 12(3):293-6. PubMed ID: 10801460.
    Abstract:
    Recently, findings regarding a group of cancer predisposition and chromosome instability syndromes, Nijmegen breakage syndrome (NBS), the ataxia-telangiectasia-like disorder (A-TLD) and ataxia telangiectasia have shed light on the unexpected role of recombinational DNA repair proteins in DNA-damage-dependent cell-cycle regulation. Mutations in the Mre11 complex cause A-TLD and NBS. In addition, functions of the Mre11 complex have been biochemically linked to ATM, the large protein kinase that is defective in ataxia-telangiectasia cells by the observation that Nbs1 is a bona fide substrate of the ATM kinase.
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