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  • Title: The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection.
    Author: Wang H, DeVries ME, Deng S, Khandaker MH, Pickering JG, Chow LH, Garcia B, Kelvin DJ, Zhong R.
    Journal: Nat Med; 2000 May; 6(5):549-55. PubMed ID: 10802711.
    Abstract:
    Recent advances using transgenic animals or exogenous complement inhibitors have demonstrated prevention of hyperacute rejection of vascularized organs, but not graft loss due to acute vascular rejection. Using various wild-type and cytokine-deficient mice strains, we have examined the mechanisms of acute vascular rejection. C57BL/6 mice deficient in interleukin12 or gamma interferon showed faster acute vascular rejection than did wild-type mice. Furthermore, mice defective in B-cell development showed no acute vascular rejection. These results demonstrate that the axis of interleukin 12 and gamma interferon provides a survival advantage in vascularized xenografts by delaying or preventing acute vascular rejection caused by a B cell-dependent mechanism.
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