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  • Title: Mechanisms of perinatal brain injury.
    Author: Inder TE, Volpe JJ.
    Journal: Semin Neonatol; 2000 Feb; 5(1):3-16. PubMed ID: 10802746.
    Abstract:
    This article is focused on the mechanisms underlying primarily ischaemic/reperfusion brain injury in both the term and premature infant. Although the mechanisms involved include similar initiating events, principally ischaemia-reperfusion, and similar final common pathways to cell death, particularly free radical-mediated events, there are certain unique maturational factors influencing the type and pattern of cellular injury. We will therefore initially describe the physiological and cellular/molecular mechanisms of brain injury in the term infant, followed by the mechanisms in the premature infant.
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