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  • Title: Induction therapy in non-small-cell lung cancer: a comparison of clinical and post-surgical staging.
    Author: Granone PL, Margaritora S, Cesario A, Galetta D.
    Journal: Ann Ital Chir; 1999; 70(6):899-903. PubMed ID: 10804669.
    Abstract:
    In the last decade, several neoadjuvant trials for NSCLC patients with mediastinal lymph node involvement (N2) have been scheduled. The uniform plan is based on clinical staging, therapy, clinical re-staging, surgery (when is possible) and, finally, pathological staging. The precise classification of tumor during the three different staging procedures is mandatory. Considering clinical re-staging and pathological staging, nowadays surgery could be considered correct for most of the patients enrolled in the neoadjuvant protocols including cases where a major clinical response has not been achieved. Several experiences demonstrated how often the clinical restaging overesteems neoplastic tissue by fibrosis and scar and could judge as unresectable patients with a minimal residual disease.
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