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  • Title: Human T-lymphocyte rosette formation: inhibition by cytochalasin B.
    Author: Cohnen G, Fischer K, Brittinger G.
    Journal: Immunology; 1975 Aug; 29(2):337-41. PubMed ID: 1080476.
    Abstract:
    The effects of cytochalasin B, colchicine and vinblastine on the rosette formation of human T lymphocytes with neuraminidase-treated human erythrocytes (nHRBC) and with sheep red blood cells (SRBC) have been studied. Pretreatment of the lymphocytes with cytochalasin B which affects microfilament action reversibly inhibits both nHRBC and SRBC rosette formation. Colchicine and vinblastine known to interact with microtubules causes no major reduction in rosette-forming cells. The results suggest that normally functioning microfilaments are necessary for nHRBC and SRBC rosetting, whereas microtubules are not essential for the blinding of the erythrocytes to the lymphocytes.
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