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  • Title: Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii.
    Author: Yun BS, Lee IK, Kim JP, Yoo ID.
    Journal: J Antibiot (Tokyo); 2000 Feb; 53(2):114-22. PubMed ID: 10805570.
    Abstract:
    In our continuous investigation for free radical scavengers from extracts of fruit body of basidiomycetes, we have isolated four new p-terphenyl compounds, designated as curtisians A-D, from the methanolic extract of the fruit body of Paxillus curtisii. These compounds were isolated by silica gel and Sephadex LH-20 column chromatographies, preparative-TLC and HPLC, consecutively. The structures of curtisians were assigned as p-terphenyls with substituents of acetyl, benzoyl, phenylbutyryl, 3-hydroxybutyryl and 3-acetoxybutyryl. Curtisians A, B, C and D exhibited inhibitory activity against lipid peroxidation with IC50, values of 0.15, 0.17, 0.24 and 0.14 microg/ml, respectively.
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