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  • Title: Lichen planus--specific antigen in oral lichen planus and oral lichenoid drug eruptions.
    Author: McCartan BE, Lamey P.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2000 May; 89(5):585-7. PubMed ID: 10807715.
    Abstract:
    OBJECTIVE: To investigate the usefulness of lichen planus-specific antigen as a marker to distinguish idiopathic oral lichen planus from oral lichenoid drug eruptions. STUDY DESIGN: Biopsy samples were taken from 6 patients with oral lichenoid drug eruptions and 6 patients with idiopathic oral lichen planus. Each biopsy sample was examined for the presence of lichen planus-specific antigen by using a modification of a previously described immunofluorescence method that uses autologous serum and also allogenic sera from the remaining 11 cases. RESULTS: All autologous and allogenic immunofluorescence tests showed negative findings for lichen planus-specific antigen. CONCLUSIONS: Lichen planus-specific antigen is not a useful marker to distinguish oral lichenoid drug eruptions from idiopathic lichen planus. This finding is in contrast with our findings in an earlier study of basal cell cytoplasmic autoantibodies.
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