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  • Title: Role of acetylcholine in regulation of interaction between axon and Schwann cell during rhythmic excitation of nerve fibers.
    Author: Maximov GV, Revin VV, Grunyushkin IP, Kols OR.
    Journal: Biochemistry (Mosc); 2000 Apr; 65(4):431-5. PubMed ID: 10810179.
    Abstract:
    Axon excitation increases the number of acetylcholine receptors (ACR) of the Schwann cell (SC) depending on the frequency of rhythmic excitation (RE) and on intercellular concentrations of K+, Ca2+, and acetylcholine. During RE, activity of axonal acetylcholine esterase is decreased, thus providing for high intercellular acetylcholine concentration. Increased intercellular concentration of acetylcholine activates phosphoinositide-specific phospholipase C (PIPLC) of the myelin nerve fiber. During RE, K+ depolarization and acetylcholine exocytosis can activate Ca2+ entry via Ca2+ channels, thus inducing SC ACR phosphorylation mediated by PIPLC stimulation.
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