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  • Title: Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog.
    Author: Espinosa de los Monteros A, Martín de las Mulas J, Fernández A, Orós J, Rodríguez F.
    Journal: Vet Pathol; 2000 May; 37(3):268-71. PubMed ID: 10810992.
    Abstract:
    A cutaneous melanocytoma-acanthoma in a 2-year-old female German Shepherd Dog was characterized by the presence of two populations of neoplastic cells: epithelial and melanocytic. The epithelial component consisted of nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes. The epithelial cells immunoreacted with both monoclonal and polyclonal anti-cytokeratin antibodies, and immunoreaction to S-100 protein and vimentin was observed in the melanocytic cells. This rare pigmented skin neoplasm of the dog apparently has a benign behavior.
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