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  • Title: Reactivity to a 35% CO2 challenge in healthy first-degree relatives of patients with panic disorder.
    Author: van Beek N, Griez E.
    Journal: Biol Psychiatry; 2000 May 01; 47(9):830-5. PubMed ID: 10812042.
    Abstract:
    BACKGROUND: The effects of a 35% CO2 challenge were examined in healthy first-degree relatives of panic disorder patients and in healthy control subjects matched for age and gender. METHODS: One single inhalation of a 35% CO2/65% O2 challenge was administered to 50 first-degree relatives of panic disorder patients and 50 control subjects. RESULTS: The first-degree relatives were more reactive to the 35% CO2 challenge than the control subjects. CONCLUSIONS: These findings indicate that being a member of a family with a panic disorder patient is, in itself an important factor in CO2 hypersensitivity among subjects who have never experienced a panic attack. Both panic disorder patients and their first-degree relatives have a tendency to be more reactive to the CO2 challenge.
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