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  • Title: Toward catalytically active oligonucleotides: synthesis of a flavin nucleotide and its incorporation into DNA.
    Author: Schwögler A, Carell T.
    Journal: Org Lett; 2000 May 18; 2(10):1415-8. PubMed ID: 10814461.
    Abstract:
    [reaction--see text] The synthesis of a vitamin B(2)-derived flavin-nucleotide is described. A combined H-phosphonate/phosphoramidite protocol was developed for the first incorporation of flavin coenzymes into a DNA stack. The coenzyme-DNA is predicted to have novel biosensing and catalytic properties.
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