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  • Title: [Fatal course of generalized BCG histiocytosis in congenital immune deficiency (author's transl)].
    Author: Heilmann K, Brehmer W, Schraegle H.
    Journal: Dtsch Med Wochenschr; 1975 Dec 19; 100(51):2604, 2607-10. PubMed ID: 1081449.
    Abstract:
    Severe combined X-linked immune deficiency ended fatally in a six-month-old male infant after generalized BCG infection. Damage in the cell-bound thymus-dependent immune system is decisive in the development of "BCG histiocytosis". As a result of absent immunocompetent sensitized T-lymphocytes there is insufficient information and stimulation of macrophages to kill the micro-organsims. The disorder of bactericidal properties of macrophages results in an overwhelming infection with BCG bacteria with a characteristic morphological picture.
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