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  • Title: [Cushing syndrome. The diagnostic and therapeutic challenges].
    Author: Mercado M, Espinosa de los Monteros AL.
    Journal: Gac Med Mex; 2000; 136(2):123-38. PubMed ID: 10815323.
    Abstract:
    Endogenous hypercortisolism is characteristically a condition that should be diagnosed and treated in tertiary care centers with the participation of several specialists. Cushing's syndrome represents the clinical expression of a prolonged exposure to glucocorticoids, independently of its origin. The term Cushing's disease refers to the hypercortisolism that results from the excessive secretion of corticotropin (ACTH) by a pituitary microadenoma. The mechanisms that give rise to the different forms of hypercortisolism are complex and its precise differential diagnosis is one of the major challenges in modern endocrinology. This review focuses on current aspects of the pathophysiology, differential diagnosis and treatment of Cushing's syndrome.
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