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  • Title: Diverse receptive fields in the lateral geniculate nucleus during thalamocortical development.
    Author: Tavazoie SF, Reid RC.
    Journal: Nat Neurosci; 2000 Jun; 3(6):608-16. PubMed ID: 10816318.
    Abstract:
    Most models of thalamocortical development in the visual system assume a homogeneous population of thalamic inputs to the cortex, each with concentric on- or off-center receptive fields. To test this, we made high-resolution spatial maps of receptive fields in the developing ferret lateral geniculate nucleus (LGN). Developing receptive fields (RFs), had a variety of shapes: some concentric, others elongated (like adult cortical receptive fields) and some with 'hot spots' of sensitivity. These receptive fields seemed to arise from convergence of multiple retinal afferents onto LGN neurons. We present a Hebbian model whereby imprecise retinogeniculate connections help refine geniculocortical connections, sharpening both thalamocortical topography and perhaps orientation selectivity.
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