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  • Title: Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium.
    Author: McSorley SJ, Jenkins MK.
    Journal: Infect Immun; 2000 Jun; 68(6):3344-8. PubMed ID: 10816483.
    Abstract:
    Resolution of infection with attenuated Salmonella is an active process that requires CD4(+) T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28(+) CD4(+) T cells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4(+) T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.
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