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  • Title: [Tilorone-induced functional changes in the rat retina].
    Author: Bredehorn T, Duncker GI.
    Journal: Klin Monbl Augenheilkd; 2000 Apr; 216(4):219-22. PubMed ID: 10820707.
    Abstract:
    BACKGROUND: The amphiphilic interferon-inducing drug tilorone belongs to the group of synthetic fluorenone with antitumorus and antiviral effects and is known to cause lipidosis in the human and rat retina. METHODS: We treated female albino Wistar-Kyoto-Rats and Spontaneously-Hypertensive-Rats orally with tilorone for 8 weeks. The animals were submitted to electroretinography, and the retinae were prepared for histological investigations. RESULTS: Tilorone caused moderate lipidosis in the ganglion cells and slight lipidosis in the pigment epithelium after 8 weeks of treatment with a stronger effect in Spontaneously-Hypertensive-Rats. The b-wave amplitude was reduced by 30% compared to controls in Spontaneously-Hypertensive-Rats and by 10% in the Wistar-Kyoto-group. The a-wave amplitude was reduced by 25% in Spontaneously-Hypertensive-Rats. CONCLUSION: Tilorone induced lipidosis shows a clear affinity to ganglion cells. The electroretinographic changes in Spontaneously-Hypertensive-Rats are most likely caused by the severe lipidosis in the neuroretina compared to the Wistar-Kyoto-group.
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