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  • Title: Extractionless determination of 6-methoxy-2-naphthylacetic acid, a major metabolite of nabumetone, in human plasma by high-performance liquid chromatography.
    Author: de Jager AD, Hundt HK, Hundt AF, Swart KJ, Knight M, Roberts J.
    Journal: J Chromatogr B Biomed Sci Appl; 2000 Apr 14; 740(2):247-51. PubMed ID: 10821411.
    Abstract:
    Following oral administration of the prodrug nabumetone, the major metabolite 6-methoxy-2-naphthylacetic acid (6-MNA) was determined in human plasma. Minimal sample preparation was followed by reversed-phase liquid chromatography and UV detection, affording high sample throughput. The lower limit of quantification (LLOQ) was 70 ng/ml, at a signal-to-noise ratio of 8:1. The assay method displayed good correlation (r=0.997), and can be readily employed in pharmacokinetic and bioequivalence studies.
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