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  • Title: Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves.
    Author: Hase A, Suzuki H, Arahata K, Akazawa C.
    Journal: Neurosci Lett; 1999 Jul 02; 269(1):55-7. PubMed ID: 10821644.
    Abstract:
    Motor neurons have been known to require a wide variety of neurotrophic factors for their survival. As one of the target-derived trophic factors, glial cell line-derived neurotrophic factor (GDNF) has been shown to exert its effects on motor neurons via a receptor complex including GDNF receptor alpha 1 (GFR alpha-1). Immunoreactivity of GFR alpha-1 was observed at myelinated peripheral nerves and neuromuscular junction (NMJ) of human skeletal muscles. Reverse transcriptase polymerase chain reaction (RT-PCR) analyses showed that mRNA of GFR alpha-1 existed in the ventral horn of human spinal cord, but not in the skeletal muscles. The results suggested that GFR alpha-1 might play a key role for uptake and internalization of GDNF at the human NMJ.
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