These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.
    Author: Borisova SA, Zhao L, Sherman DH, Liu HW.
    Journal: Org Lett; 1999 Jul 15; 1(1):133-6. PubMed ID: 10822548.
    Abstract:
    [formula: see text] The appended sugars in macrolide antibiotics are indispensable to the biological activities of these important drugs. In an effort to generate a set of novel macrolide derivatives, we have created a new analogue of methymycin and neomethymycin, antibiotics produced by Streptomyces venezuelae. This analogue 15 carrying a different sugar, D-quinovose, instead of D-desosamine, was constructed by taking advantage of targeted gene deletion combined with a specific pathway-independent C-3 reduction capability of the wild type S. venezuelae.
    [Abstract] [Full Text] [Related] [New Search]