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  • Title: A non-linear voltage dependent charge movement in frog skeletal muscle.
    Author: Chandler WK, Rakowski RF, Schneider MF.
    Journal: J Physiol; 1976 Jan; 254(2):245-83. PubMed ID: 1082506.
    Abstract:
    1. Voltage-clamp experiments were carried out using the three microelectrode technique. Using this method membrane current density at V1 is proportional to deltaV( = V2 - V1) where V1 and V2 are voltages at distances 1 and 21 from the end of a fibre. Voltage dependent sodium currents were blocked by tetrodotoxin, potassium by tetraethylammonium ions and rubidium. Contraction was blocked by adding sucrose, 467 mM. 2. The current deltaV (control) associated with a positive voltage step from a hyperpolarized conditioning voltage to the holding potential, -80 mV, showed two components, a capacitative transient which decayed rapidly and a maintained steady level...
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